Impact of food load test on microcirculation parameters in the liver of rats of different gender and age

Introduction. One of the promising directions studying liver microcirculation is searching for age-related features its hemodynamics and early markers pathological changes. Objective – to study parameters in animals different sex age during a load test. Materials methods. The was conducted on 60 mongrel rats both sexes weighing 120–270 g, divided into three groups. first group included 20 aged 1 month, second 6–12 months third more than 18–24 months. performed using laser Doppler flowmeter LAKK-02 (Russia) under zoletil-xylazine anesthesia. Then, were injected per os with mixture enteral nutrition Nutridrink (Nutricia) ratio 5 mg/kg body weight. After 15 minutes determined again. Digital data processed by methods variation statistics. Results. In rats, basic slightly higher females compared males: 8.22 % (R=0.31) I, 8.66 (R= 0.05) II 1.19 (R=0.48) III group. With an increase animals, indicators decreased. test, indexes noted all groups: 45.13 (R=0.82) 27.99 (R=0.64) 15.88 (R=0.91) Conclusion. There no statistically significant dependence animals. rat’s age, rates food test after significantly